A20V (p.Ala20Val) variant of FOS (Protein c-Fos)
A20V (p.Ala20Val) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, published literature, and structural context.
A20V (p.Ala20Val) variant details
- p.Ala20Val
- gnomAD 14-75279041-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.446
- REVEL 0.21
- MetaLR 0.44
- MetaSVM -0.15
- CADD 28.30
- PolyPhen-2 0.98
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available
- Literature evidence available