S4L (p.Ser4Leu) variant of FOS (Protein c-Fos)
S4L (p.Ser4Leu) in FOS (Protein c-Fos) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data.
S4L (p.Ser4Leu) variant details
- p.Ser4Leu
- rs1359533864
- NCI-TCGA Cosmic COSV1003
- cosmic curated COSV10033
- TOPMed rs1359533864
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.325
- REVEL 0.06
- MetaLR 0.15
- MetaSVM -0.86
- CADD 23.30
- PolyPhen-2 0.01
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)