A12V (p.Ala12Val) variant of FOS (Protein c-Fos)
A12V (p.Ala12Val) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
A12V (p.Ala12Val) variant details
- p.Ala12Val
- ExAC rs749267828
- TOPMed rs749267828
- gnomAD rs749267828
- Missense
- Variant Prioritization Score for Impact Estimate 0.36
- REVEL 0.15
- MetaLR 0.40
- MetaSVM -0.27
- CADD 29.50
- PolyPhen-2 0.98
- SIFT 0.10
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available