I61T (p.Ile61Thr) variant of FOS (Protein c-Fos)
I61T (p.Ile61Thr) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, published literature, and structural context.
I61T (p.Ile61Thr) variant details
- p.Ile61Thr
- gnomAD 14-75279917-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.388
- REVEL 0.27
- MetaLR 0.18
- MetaSVM -0.70
- CADD 24.70
- PolyPhen-2 0.12
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available