F49L (p.Phe49Leu) variant of FOS (Protein c-Fos)
F49L (p.Phe49Leu) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
F49L (p.Phe49Leu) variant details
- p.Phe49Leu
- gnomAD rs1397471123
- Missense
- Variant Prioritization Score for Impact Estimate 0.353
- REVEL 0.14
- MetaLR 0.09
- MetaSVM -1.07
- CADD 19.10
- PolyPhen-2 0.00
- SIFT 0.28
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available