M40L (p.Met40Leu) variant of FOS (Protein c-Fos)
M40L (p.Met40Leu) in FOS (Protein c-Fos) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
M40L (p.Met40Leu) variant details
- p.Met40Leu
- ExAC rs758695063
- gnomAD rs758695063
- Missense
- Variant Prioritization Score for Impact Estimate 0.216
- REVEL 0.14
- MetaLR 0.08
- MetaSVM -1.05
- CADD 20.20
- PolyPhen-2 0.00
- SIFT 0.58
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available