FLT3 (P36888) variants and mutations

FLT3 (also known as P36888) is a human protein-coding gene encoding a receptor-type tyrosine-protein kinase protein. Its signaling supports survival and expansion of early hematopoietic progenitors. Internal tandem duplications and kinase-domain mutations produce constitutive activity in acute myeloid leukemia and are important prognostic markers and therapeutic targets. This analysis covers 2,018 FLT3 variants and mutations. Of these, 73% have computational variant effect predictions. Disease context includes acute myeloid leukemia, hepatocellular carcinoma, and gastrointestinal stromal tumor. Example FLT3 variants include P2L, P2Q, and P2R.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable FLT3 variants

Examples include P2L, P2Q, P2R, P2S, A3V, L4*, L4S, L4V. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.