D84N (p.Asp84Asn) variant of FLT3 (P36888)
D84N (p.Asp84Asn) in FLT3 (P36888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
D84N (p.Asp84Asn) variant details
- p.Asp84Asn
- rs1235103983
- NCI-TCGA Cosmic COSV9960
- TOPMed rs1235103983
- gnomAD rs1235103983
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.23
- REVEL 0.04
- MetaLR 0.05
- MetaSVM -1.05
- CADD 12.90
- PolyPhen-2 0.00
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 5.9e-05)
- Structural context available