H40R (p.His40Arg) variant of FLT3 (P36888)
H40R (p.His40Arg) in FLT3 (P36888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
H40R (p.His40Arg) variant details
- p.His40Arg
- ExAC rs775176653
- gnomAD rs775176653
- Missense
- Variant Prioritization Score for Impact Estimate 0.367
- REVEL 0.31
- MetaLR 0.24
- MetaSVM -0.87
- CADD 19.70
- PolyPhen-2 0.00
- SIFT 0.13
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available