D84G (p.Asp84Gly) variant of FLT3 (P36888)
D84G (p.Asp84Gly) in FLT3 (P36888) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
D84G (p.Asp84Gly) variant details
- p.Asp84Gly
- rs778119340
- ClinGen CA6928968
- ClinVar RCV004111355
- ExAC rs778119340
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.185
- REVEL 0.08
- MetaLR 0.05
- MetaSVM -1.04
- CADD 15.90
- PolyPhen-2 0.01
- SIFT 0.38
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available