G64W (p.Gly64Trp) variant of FLT3 (P36888)
G64W (p.Gly64Trp) in FLT3 (P36888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
G64W (p.Gly64Trp) variant details
- p.Gly64Trp
- rs376895552
- NCI-TCGA Cosmic COSV5405
- ESP rs376895552
- ExAC rs376895552
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.384
- REVEL 0.31
- MetaLR 0.44
- MetaSVM -0.43
- CADD 22.30
- PolyPhen-2 0.77
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available