V16L (p.Val16Leu) variant of FLT3 (P36888)
V16L (p.Val16Leu) in FLT3 (P36888) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
V16L (p.Val16Leu) variant details
- p.Val16Leu
- rs62636526
- ClinGen CA159813
- ClinVar RCV000121118
- ClinVar RCV000898151
- Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.296
- REVEL 0.28
- MetaLR 0.37
- MetaSVM -0.53
- CADD 15.90
- PolyPhen-2 0.98
- SIFT 0.16
- ClinVar: Likely benign (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the HGDP:MBUTI population (allele frequency 0.042)
- Structural context available