L63F (p.Leu63Phe) variant of FLT3 (P36888)
L63F (p.Leu63Phe) in FLT3 (P36888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.50 / 1. The record also includes population frequency data and structural context.
L63F (p.Leu63Phe) variant details
- p.Leu63Phe
- TOPMed rs1876617733
- Missense
- Variant Prioritization Score for Impact Estimate 0.5
- REVEL 0.36
- MetaLR 0.61
- MetaSVM 0.25
- CADD 23.90
- PolyPhen-2 1.00
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available