A66T (p.Ala66Thr) variant of FLT3 (P36888)
A66T (p.Ala66Thr) in FLT3 (P36888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
A66T (p.Ala66Thr) variant details
- p.Ala66Thr
- rs572460566
- NCI-TCGA Cosmic COSV5406
- ExAC rs572460566
- TOPMed rs572460566
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.109
- REVEL 0.05
- MetaLR 0.20
- MetaSVM -0.97
- CADD 6.23
- PolyPhen-2 0.00
- SIFT 0.39
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 5.9e-05)
- Structural context available