D84V (p.Asp84Val) variant of FLT3 (P36888)
D84V (p.Asp84Val) in FLT3 (P36888) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
D84V (p.Asp84Val) variant details
- p.Asp84Val
- ExAC rs778119340
- TOPMed rs778119340
- gnomAD rs778119340
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.227
- REVEL 0.15
- MetaLR 0.05
- MetaSVM -1.04
- CADD 18.60
- PolyPhen-2 0.01
- SIFT 0.01
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 0.00013)
- Structural context available