P116R (p.Pro116Arg) variant of FLT3 (P36888)
P116R (p.Pro116Arg) in FLT3 (P36888) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
P116R (p.Pro116Arg) variant details
- p.Pro116Arg
- rs368416225
- ClinGen CA6928950
- ClinVar RCV000920721
- 1000Genomes rs368416225
- Likely benign
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.384
- REVEL 0.19
- MetaLR 0.06
- MetaSVM -1.06
- CADD 23.40
- PolyPhen-2 0.19
- SIFT 0.22
- ClinVar: Likely benign (not provided)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the 1KG:PJL population (allele frequency 0.021)
- Structural context available