I89L (p.Ile89Leu) variant of FLT3 (P36888)
I89L (p.Ile89Leu) in FLT3 (P36888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
I89L (p.Ile89Leu) variant details
- p.Ile89Leu
- TOPMed rs1383394847
- gnomAD rs1383394847
- Missense
- Variant Prioritization Score for Impact Estimate 0.111
- REVEL 0.03
- MetaLR 0.05
- MetaSVM -1.06
- CADD 15.10
- PolyPhen-2 0.01
- SIFT 0.16
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available