L37S (p.Leu37Ser) variant of FLT3 (P36888)
L37S (p.Leu37Ser) in FLT3 (P36888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
L37S (p.Leu37Ser) variant details
- p.Leu37Ser
- rs1238533990
- NCI-TCGA Cosmic COSV5405
- gnomAD rs1238533990
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.562
- REVEL 0.53
- MetaLR 0.55
- MetaSVM 0.13
- CADD 26.10
- PolyPhen-2 0.92
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available