R68G (p.Arg68Gly) variant of FLT3 (P36888)
R68G (p.Arg68Gly) in FLT3 (P36888) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
R68G (p.Arg68Gly) variant details
- p.Arg68Gly
- ESP rs201649330
- ExAC rs201649330
- TOPMed rs201649330
- gnomAD rs201649330
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.381
- REVEL 0.29
- MetaLR 0.25
- MetaSVM -0.86
- CADD 9.11
- PolyPhen-2 0.02
- SIFT 0.22
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 0.0001)
- Structural context available