K41E (p.Lys41Glu) variant of FLT3 (P36888)
K41E (p.Lys41Glu) in FLT3 (P36888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
K41E (p.Lys41Glu) variant details
- p.Lys41Glu
- rs139579569
- NCI-TCGA Cosmic COSV5407
- ESP rs139579569
- ExAC rs139579569
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.195
- REVEL 0.13
- MetaLR 0.20
- MetaSVM -0.96
- CADD 17.40
- PolyPhen-2 0.00
- SIFT 0.10
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 0.00016)
- Structural context available