P12L (p.Pro12Leu) variant of FLT3 (P36888)
P12L (p.Pro12Leu) in FLT3 (P36888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
P12L (p.Pro12Leu) variant details
- p.Pro12Leu
- TOPMed rs1472287571
- gnomAD rs1472287571
- Missense
- Variant Prioritization Score for Impact Estimate 0.215
- REVEL 0.12
- MetaLR 0.16
- MetaSVM -0.92
- CADD 20.40
- PolyPhen-2 0.00
- SIFT 0.86
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available