S18F (p.Ser18Phe) variant of FLT3 (P36888)
S18F (p.Ser18Phe) in FLT3 (P36888) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; high impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
S18F (p.Ser18Phe) variant details
- p.Ser18Phe
- NCI-TCGA TCGA novel
- Variant assessed as somatic; high impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.411
- REVEL 0.35
- MetaLR 0.47
- MetaSVM -0.44
- CADD 24.10
- PolyPhen-2 0.92
- SIFT 0.01
- UniProt: Variant assessed as somatic; high impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available