F22S (p.Phe22Ser) variant of FLT3 (P36888)
F22S (p.Phe22Ser) in FLT3 (P36888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
F22S (p.Phe22Ser) variant details
- p.Phe22Ser
- TOPMed rs1334799394
- gnomAD rs1334799394
- Missense
- Variant Prioritization Score for Impact Estimate 0.369
- REVEL 0.44
- MetaLR 0.26
- MetaSVM -0.80
- CADD 19.10
- PolyPhen-2 0.04
- SIFT 0.15
- Most common in the Latino/Admixed American population (allele frequency 0.00013)
- Structural context available