F22C (p.Phe22Cys) variant of FLT3 (P36888)
F22C (p.Phe22Cys) in FLT3 (P36888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
F22C (p.Phe22Cys) variant details
- p.Phe22Cys
- TOPMed rs1334799394
- gnomAD rs1334799394
- Missense
- Variant Prioritization Score for Impact Estimate 0.206
- REVEL 0.12
- MetaLR 0.25
- MetaSVM -0.81
- CADD 18.20
- PolyPhen-2 0.00
- SIFT 0.07
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available