D62G (p.Asp62Gly) variant of FLT3 (P36888)
D62G (p.Asp62Gly) in FLT3 (P36888) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
D62G (p.Asp62Gly) variant details
- p.Asp62Gly
- rs1029573584
- ClinGen CA247277728
- ClinVar RCV004389530
- TOPMed rs1029573584
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.583
- REVEL 0.56
- MetaLR 0.59
- MetaSVM 0.22
- CADD 25.40
- PolyPhen-2 1.00
- SIFT 0.05
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 0.00066)
- Structural context available