I33M (p.Ile33Met) variant of FLT3 (P36888)
I33M (p.Ile33Met) in FLT3 (P36888) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.43 / 1. The record also includes population frequency data and structural context.
I33M (p.Ile33Met) variant details
- p.Ile33Met
- ExAC rs768002750
- gnomAD rs768002750
- Missense
- Variant Prioritization Score for Impact Estimate 0.429
- REVEL 0.44
- MetaLR 0.45
- MetaSVM -0.38
- CADD 23.70
- PolyPhen-2 0.99
- SIFT 0.13
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available