CD4 (T-cell surface glycoprotein CD4) variants and mutations

CD4 (also known as T-cell surface glycoprotein CD4) is a human protein-coding gene encoding a t-cell surface glycoprotein protein. It acts as a coreceptor for MHC class II recognition and helps recruit LCK to amplify antigen-receptor signaling in helper T cells. It is also the primary cellular receptor used by HIV for entry into susceptible immune cells. This analysis covers 712 CD4 variants and mutations. Of these, 96% have computational variant effect predictions. Disease context includes HIV infectious disease, immunodeficiency 79, and Okt4 epitope deficiency. Example CD4 variants include M1V, N2S, and N2T.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, Protein Data Bank, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CD4 variants

Examples include M1V, N2S, N2T, N2I, R3L, R3Q, R3W, R3R. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.