R3W (p.Arg3Trp) variant of CD4 (T-cell surface glycoprotein CD4)
R3W (p.Arg3Trp) in CD4 (T-cell surface glycoprotein CD4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
R3W (p.Arg3Trp) variant details
- p.Arg3Trp
- rs201040272
- NCI-TCGA Cosmic COSV5059
- cosmic curated COSV50596
- 1000Genomes rs201040272
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.19
- REVEL 0.22
- MetaLR 0.13
- MetaSVM -1.03
- CADD 7.63
- PolyPhen-2 0.00
- SIFT 0.10
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available