R79H (p.Arg79His) variant of CD4 (T-cell surface glycoprotein CD4)
R79H (p.Arg79His) in CD4 (T-cell surface glycoprotein CD4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
R79H (p.Arg79His) variant details
- p.Arg79His
- NCI-TCGA Cosmic COSV5058
- cosmic curated COSV50589
- Ensembl rs1943021607
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.392
- REVEL 0.28
- MetaLR 0.48
- MetaSVM -0.48
- CADD 23.10
- PolyPhen-2 0.99
- SIFT 0.03
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available