S44C (p.Ser44Cys) variant of CD4 (T-cell surface glycoprotein CD4)
S44C (p.Ser44Cys) in CD4 (T-cell surface glycoprotein CD4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, published literature, and structural context.
S44C (p.Ser44Cys) variant details
- p.Ser44Cys
- gnomAD 12-6800388-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.437
- REVEL 0.40
- MetaLR 0.53
- MetaSVM -0.02
- CADD 22.00
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available
- Literature evidence available