I49V (p.Ile49Val) variant of CD4 (T-cell surface glycoprotein CD4)
I49V (p.Ile49Val) in CD4 (T-cell surface glycoprotein CD4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data, published literature, and structural context.
I49V (p.Ile49Val) variant details
- p.Ile49Val
- gnomAD 12-6800402-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.099
- REVEL 0.08
- MetaLR 0.06
- MetaSVM -1.00
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 0.60
- Most common in the African/African-American population (allele frequency 0.00031)
- Structural context available
- Literature evidence available