L14P (p.Leu14Pro) variant of CD4 (T-cell surface glycoprotein CD4)
L14P (p.Leu14Pro) in CD4 (T-cell surface glycoprotein CD4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, published literature, and structural context.
L14P (p.Leu14Pro) variant details
- p.Leu14Pro
- gnomAD 12-6800179-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.533
- REVEL 0.57
- MetaLR 0.38
- MetaSVM -0.27
- CADD 26.00
- PolyPhen-2 1.00
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available
- Literature evidence available