L18F (p.Leu18Phe) variant of CD4 (T-cell surface glycoprotein CD4)
L18F (p.Leu18Phe) in CD4 (T-cell surface glycoprotein CD4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, published literature, and structural context.
L18F (p.Leu18Phe) variant details
- p.Leu18Phe
- gnomAD 12-6800309-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.236
- REVEL 0.04
- MetaLR 0.08
- MetaSVM -1.03
- CADD 15.20
- PolyPhen-2 0.74
- SIFT 0.04
- Most common in the HGDP:BURUSHO population (allele frequency 0.042)
- Structural context available
- Literature evidence available