A80V (p.Ala80Val) variant of CD4 (T-cell surface glycoprotein CD4)
A80V (p.Ala80Val) in CD4 (T-cell surface glycoprotein CD4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
A80V (p.Ala80Val) variant details
- p.Ala80Val
- rs1239818302
- NCI-TCGA Cosmic COSV9916
- cosmic curated COSV99163
- TOPMed rs1239818302
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0883
- REVEL 0.05
- MetaLR 0.10
- MetaSVM -0.96
- CADD 0.01
- PolyPhen-2 0.00
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)
- Structural context available