K46R (p.Lys46Arg) variant of CD4 (T-cell surface glycoprotein CD4)
K46R (p.Lys46Arg) in CD4 (T-cell surface glycoprotein CD4) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data, published literature, and structural context.
K46R (p.Lys46Arg) variant details
- p.Lys46Arg
- gnomAD 12-6800394-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.106
- REVEL 0.05
- MetaLR 0.21
- MetaSVM -0.89
- CADD 5.80
- PolyPhen-2 0.05
- SIFT 0.11
- Most common in the African/African-American population (allele frequency 0.00041)
- Structural context available
- Literature evidence available