A17V (p.Ala17Val) variant of CD4 (T-cell surface glycoprotein CD4)
A17V (p.Ala17Val) in CD4 (T-cell surface glycoprotein CD4) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data and structural context.
A17V (p.Ala17Val) variant details
- p.Ala17Val
- rs199744985
- ExAC rs199744985
- TOPMed rs199744985
- gnomAD rs199744985
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0669
- REVEL 0.03
- MetaLR 0.03
- MetaSVM -0.99
- CADD 0.30
- PolyPhen-2 0.00
- SIFT 0.25
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available