CD8B (P10966) variants and mutations

CD8B (also known as P10966) is a human protein-coding gene encoding a t-cell surface glycoprotein CD8 beta chain protein. It pairs with CD8A to form the predominant CD8 coreceptor on cytotoxic T cells, stabilizing interactions with MHC class I and facilitating antigen-receptor signaling. Disruption can impair development or function of the CD8 T-cell compartment. This analysis covers 381 CD8B variants and mutations. Of these, 95% have computational variant effect predictions. Disease context includes HIV infectious disease, Jaundice, and stroke disorder. Example CD8B variants include R2Q, R2W, and P3L.

Variant analysis overview

Variant and mutation evidence

Clinical, disease, and population context

Protein structure and variant hotspots

Data sources

Evidence in this analysis draws on EBI Proteins Variation, UniProt, gnomAD v4, EuropePMC, 3D Hotspot Analysis, Interaction Network Analysis, AlphaFold DB, gnomAD constraint, Open Targets, MaveDB, LitVar.

Notable CD8B variants

Examples include R2Q, R2W, P3L, P3Q, P3R, R4L, R4P, L5M. Listed records include available protein-change notation, database identifiers, clinical classifications, computational predictions, population evidence, experimental measurements, and disease context.