F93L (p.Phe93Leu) variant of CD8B (P10966)
F93L (p.Phe93Leu) in CD8B (P10966) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
F93L (p.Phe93Leu) variant details
- p.Phe93Leu
- ExAC rs771926098
- TOPMed rs771926098
- gnomAD rs771926098
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.11
- REVEL 0.07
- MetaLR 0.11
- MetaSVM -1.05
- CADD 5.10
- PolyPhen-2 0.00
- SIFT 0.73
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the HGDP:DRUZE population (allele frequency 0.057)
- Structural context available