V119F (p.Val119Phe) variant of CD8B (P10966)
V119F (p.Val119Phe) in CD8B (P10966) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
V119F (p.Val119Phe) variant details
- p.Val119Phe
- 1000Genomes rs375735227
- ESP rs375735227
- ExAC rs375735227
- TOPMed rs375735227
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.132
- REVEL 0.13
- MetaLR 0.18
- MetaSVM -0.88
- CADD 0.69
- PolyPhen-2 0.81
- SIFT 0.07
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the African/African-American population (allele frequency 9.7e-05)
- Structural context available