L22F (p.Leu22Phe) variant of CD8B (P10966)
L22F (p.Leu22Phe) in CD8B (P10966) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
L22F (p.Leu22Phe) variant details
- p.Leu22Phe
- cosmic curated COSV58927
- ESP rs146795196
- ExAC rs146795196
- TOPMed rs146795196
- Missense
- Variant Prioritization Score for Impact Estimate 0.263
- REVEL 0.20
- MetaLR 0.42
- MetaSVM -0.63
- CADD 20.80
- SIFT 0.10
- Most common in the African/African-American population (allele frequency 4.9e-05)
- Structural context available