R58C (p.Arg58Cys) variant of CD8B (P10966)
R58C (p.Arg58Cys) in CD8B (P10966) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
R58C (p.Arg58Cys) variant details
- p.Arg58Cys
- rs774522740
- ExAC rs774522740
- TOPMed rs774522740
- gnomAD rs774522740
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.2
- REVEL 0.10
- MetaLR 0.21
- MetaSVM -0.79
- CADD 13.40
- PolyPhen-2 0.06
- SIFT 0.28
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 0.0001)
- Structural context available