V119I (p.Val119Ile) variant of CD8B (P10966)
V119I (p.Val119Ile) in CD8B (P10966) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
V119I (p.Val119Ile) variant details
- p.Val119Ile
- rs375735227
- ClinGen CA1751554
- NCI-TCGA Cosmic COSV5892
- cosmic curated COSV58925
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0796
- REVEL 0.04
- MetaLR 0.06
- MetaSVM -1.01
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 1.00
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the 1KG:ITU population (allele frequency 0.0049)
- Structural context available