R98L (p.Arg98Leu) variant of CD8B (P10966)
R98L (p.Arg98Leu) in CD8B (P10966) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
R98L (p.Arg98Leu) variant details
- p.Arg98Leu
- ExAC rs768017195
- TOPMed rs768017195
- gnomAD rs768017195
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.114
- REVEL 0.06
- MetaLR 0.16
- MetaSVM -0.98
- CADD 7.71
- PolyPhen-2 0.02
- SIFT 0.06
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available