I45T (p.Ile45Thr) variant of CD8B (P10966)
I45T (p.Ile45Thr) in CD8B (P10966) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
I45T (p.Ile45Thr) variant details
- p.Ile45Thr
- rs761248929
- ClinGen CA1751601
- ClinVar RCV004107083
- ExAC rs761248929
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.0982
- REVEL 0.08
- MetaLR 0.02
- MetaSVM -1.05
- CADD 0.06
- PolyPhen-2 0.00
- SIFT 1.00
- ClinVar: Likely benign (not specified)
- EBI: Likely benign
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available