R4L (p.Arg4Leu) variant of CD8B (P10966)
R4L (p.Arg4Leu) in CD8B (P10966) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
R4L (p.Arg4Leu) variant details
- p.Arg4Leu
- TOPMed rs964575377
- gnomAD rs964575377
- Missense
- Variant Prioritization Score for Impact Estimate 0.3
- REVEL 0.07
- MetaLR 0.18
- MetaSVM -1.02
- CADD 13.00
- PolyPhen-2 0.73
- SIFT 0.17
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available