E123K (p.Glu123Lys) variant of CD8B (P10966)
E123K (p.Glu123Lys) in CD8B (P10966) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
E123K (p.Glu123Lys) variant details
- p.Glu123Lys
- rs749133219
- ExAC rs749133219
- TOPMed rs749133219
- gnomAD rs749133219
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0954
- REVEL 0.07
- MetaLR 0.12
- MetaSVM -0.97
- CADD 0.03
- PolyPhen-2 0.03
- SIFT 0.28
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 0.0001)
- Structural context available