P61S (p.Pro61Ser) variant of CD8B (P10966)
P61S (p.Pro61Ser) in CD8B (P10966) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
P61S (p.Pro61Ser) variant details
- p.Pro61Ser
- rs967089228
- NCI-TCGA Cosmic COSV1005
- cosmic curated COSV10051
- TOPMed rs967089228
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.173
- REVEL 0.08
- MetaLR 0.08
- MetaSVM -1.05
- CADD 11.20
- PolyPhen-2 0.28
- SIFT 0.08
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available