L22I (p.Leu22Ile) variant of CD8B (P10966)
L22I (p.Leu22Ile) in CD8B (P10966) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
L22I (p.Leu22Ile) variant details
- p.Leu22Ile
- ESP rs146795196
- ExAC rs146795196
- TOPMed rs146795196
- gnomAD rs146795196
- Missense
- Variant Prioritization Score for Impact Estimate 0.251
- REVEL 0.18
- MetaLR 0.33
- MetaSVM -0.77
- CADD 19.40
- PolyPhen-2 0.82
- SIFT 0.12
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available