D74N (p.Asp74Asn) variant of CD8B (P10966)
D74N (p.Asp74Asn) in CD8B (P10966) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
D74N (p.Asp74Asn) variant details
- p.Asp74Asn
- rs767948136
- NCI-TCGA Cosmic COSV5892
- cosmic curated COSV58928
- ExAC rs767948136
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.159
- REVEL 0.03
- MetaLR 0.18
- MetaSVM -0.97
- CADD 4.12
- PolyPhen-2 0.04
- SIFT 0.38
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available