R4P (p.Arg4Pro) variant of CD8B (P10966)
R4P (p.Arg4Pro) in CD8B (P10966) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
R4P (p.Arg4Pro) variant details
- p.Arg4Pro
- TOPMed rs964575377
- gnomAD rs964575377
- Missense
- Variant Prioritization Score for Impact Estimate 0.341
- REVEL 0.12
- MetaLR 0.22
- MetaSVM -1.02
- CADD 17.50
- PolyPhen-2 0.93
- SIFT 0.13
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available